OncoPortal™ Knowledge Base

Where evidence, guidelines, and data play as one
OncoPortal™ Knowledge Base enriches somatic variant interpretation. Directly embeded in the SOPHiA DDM™ Platform, it delivers tiered, evidence-based annotations, bringing structured real-world context into somatic analysis, and enabling laboratories to move seamlessly from detection to actionable insights. All the context you need. Right where you need it.

Putting genomic findings into actionable real-world context

Match somatic variants, variant combinations, and biomarkers to their real-world context — unlocking actionable insights from published literature on therapy response, guideline-based tier classifications, and clinical trial references, all within a streamlined SOPHiA DDM™ workflow.
Maximize efficiency
OncoPortal™ Knowledge Base is fully integrated into the streamlined SOPHiA DDM™ workflow, reducing time per case.
Reveal actionable insights
Comprehensive information from expertly curated content and guidelines place genomic findings into actionable real-world context.
Customize your analysis

The user-friendly interface provides at-a-glance visualization of bespoke, actionable insights for streamlined variant interpretation.

Place genomic findings into actionable real-world context

Variant tier classification
Variants are assigned tiers (I-IV) based on the AMP/ASCO/CAP standards and guidelines for the interpretation and reporting of somatic variants.
Guideline & regulatory driven insights
Insights from guidelines (NCCN/ESMO) and regulatory approvals (FDA/EMA/TGA/ANVISA) are highlighted, supported by scientific literature.
Molecular profile actionability
Explore the compound effect of multiple co-occurring variants and biomarkers matched against literature on therapy responses, prognosis, diagnosis, and cancer biology.
Clinical trial references
Surface relevant clinical trial references matched to individual variants and variant combinations. Filter by country/state and disease area to focus your analysis.
Comprehensive reporting

Key variant information, actionable insights, and personalized annotations and interpretations can be added to your report in just a few clicks.

Up-to-date knowledge base

The OncoPortal™ Knowledge Base is powered by the Genomenon Cancer Knowledgebase (CKB) a comprehensive and up-to-date knowledge base, manually expanded with curations and user contributions.
  • >2,200 cancer genes
  • >49,000 variants
  • >16,000 clinical trial references
  • >4,000 references on targeted therapies
* Somatic gene and variant annotations and related content have been powered by Genomenon Clinical Knowledgebase (CKB) https://ckb.jax.org/about/index
OncoPortal™ Knowledge Base, when used alongside SOPHiA DDM™ solutions, is for informational use only and should not be used for diagnostic procedures or patient management.

SOPHiA GENETICS products are for Research Use Only and not for use in diagnostic procedures unless specified otherwise.

SOPHiA DDM™ Dx Hereditary Cancer Solution, SOPHiA DDM™ Dx RNAtarget Oncology Solution and SOPHiA DDM™ Dx Homologous Recombination Deficiency Solution are available as CE-IVD products for In Vitro Diagnostic Use in the European Economic Area (EEA), the United Kingdom and Switzerland. SOPHiA DDM™ Dx Myeloid Solution and SOPHiA DDM™ Dx Solid Tumor Solution are available as CE-IVD products for In Vitro Diagnostic Use in the EEA, the United Kingdom, Switzerland, and Israel. Information about products that may or may not be available in different countries and if applicable, may or may not have received approval or market clearance by a governmental regulatory body for different indications for use. Please contact us to obtain the appropriate product information for your country of residence.

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