SOPHiA DDM™
for Genomics

Achieve best-in-class accuracy for your genomic analysis

Accelerate confident decision-making in Oncology and Rare & Inherited Disorders with end-to-end genomics workflows for streamlined sequencing data analysis and interpretation. Reach accurate variant detection, simplified variant prioritization, and expedited reporting.

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Overcome bottlenecks and increase confidence in your results

SOPHiA DDM™ is a leading IVDR-certified* genomics platform that leverages AI algorithms to accurately pinpoint signals within noisy, complex next-generation-sequencing (NGS) datasets. It seamlessly integrates into any genomics workflow to identify causative variants.

*When used in Dx mode

Best-in-class accuracy

Detect challenging variants with high confidence using our AI/machine learning algorithms, which excel at calling complex and diverse variant types.

Universal compatibility

Effortlessly integrate our technology-agnostic analytical platform into your existing laboratory setup for any Oncology or Rare & Inherited Disorder application.

Accelerated workflows

Dramatically expedite your interpretation by removing genomic variant analysis barriers with the SOPHiA DDM™’s annotation and pre-classification capabilities.

Democratizing
data-driven medicine

1. Login and data upload

2. Data visualization

3. 3D segmentation

4. Feature extraction

5. Analysis and reporting

Improve accuracy

Utilize robust AI-powered algorithms to derive deep insights from complex data.

Expedite turnaround times

Utilize robust AI-powered algorithms to derive deep insights from complex data.

Accelerate adoption of precision medicine

Utilize robust AI-powered algorithms to derive deep insights from complex data.

Optimize resources

Utilize robust AI-powered algorithms to derive deep insights from complex data.

Accelerate adoption of precision medicine

Utilize robust AI-powered algorithms to derive deep insights from complex data.

From data to decisions, faster than ever

1. Data upload

2. Variant calling and annotation

3. Prioritization and filtering

4. Exploration and interpretation

5. Reporting

Securely log in to our cloud-based platform with 2-step verification. Quickly upload FASTQ files and select from performance pipelines tailored to sample type, chemistry, enrichment kit, and sequencer.

Assess multiple variant types within a single experiment without needing deep bioinformatics expertise. Our somatic and germline pipelines are optimized for targeted to genome-sized applications and provide comprehensive annotation with up-to-date information from >55 world-renowned curated databases, guidelines, and predictors.

Leverage machine learning and guideline-driven ranking to automatically assign pathogenicity levels to identified variants. Through our user-friendly interface, easily apply multiple filtering functions to focus on disease-specific variants, create custom filtering strategies, and/or filter by inheritance mode.

Utilize robust AI-powered algorithms to derive deep insights from complex data.

Add context to your variant interpretation. Flag variants and share insights with your disease-specific peer network or the entire SOPHiA GENETICS Community. Enhance your interpretation with direct access to the add-on modules OncoPortal™ and Alamut™ Visual Plus, that provide deeper, more comprehensive insights into your findings.

Easily generate customized reports using provided templates. Reports are CAP- and CLIA-compliant and include guideline-driven information to support decision making.

Securely log in to our cloud-based platform with 2-step verification. Quickly upload FASTQ files and select from performance pipelines tailored to sample type, chemistry, enrichment kit, and sequencer.

Chart new paths in genomics analysis
with SOPHiA DDM™

Choose the application tailored to your needs

There are three ways to leverage the power of SOPHiA DDMTM in your lab, depending on your unique capabilities and requirements.

Solid Tumors

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data.” for Genomics.

Blood Cancers

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data.” for Genomics.

Hereditary Cancers

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data.” for Genomics.

Liquid Biopsy

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data.” for Genomics.

Rare Disorders

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data.” for Genomics.

Inherited Disorders

The SOPHiA DDM™ Platform uses machine learning with patented algorithms to efficiently call, annotate, and pre-classify variants from raw NGS data.” for Genomics.

Universally compatible, infinitely powerful

There are three ways to leverage the power of SOPHiA DDM™ in your institution, depending on your unique capabilities and requirements.

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DRY LAB

Dry lab

Process samples with your in-house consumables and instruments, then accurately and securely analyze your data with the SOPHiA DDM™ Platform for rapid, community-powered insights.

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BUNDLE

Bundle

Achieve precise results in your institution with SOPHiA DDM™ sample-to-report applications, including library preparation consumables and tailored analytics for streamlined workflows.

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DRY LAB

Integrated

Connect with certified sequencing partners through SOPHiA DDM™ Integrated Access Mode, while maintaining full control of your data uploaded to SOPHiA DDM™ for analysis.

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SOPHiA DDM™ in action

Watch how you can streamline your genomics workflow during this 4-minute tutorial video that walks through the key user-friendly features of SOPHiA DDM™ for variant analysis and interpretation.

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SOPHiA DDM™ is CE marked under IVDR

IVDR certification validates the powerful analytical capabilities of the
SOPHiA DDM™ Platform for supporting patient diagnostics in the EU and beyond*. SOPHiA DDM^™ is a single platform supporting IVD and RUO applications. Certification provides proof of compliance with regulatory requirements, reducing the burden for healthcare institutions when implementing in vitro diagnostic workflows.

*When used in Dx mode.

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Conquer new summits in data-driven medicine

There are three ways to leverage the power of SOPHiA DDMTM in your lab, depending on your unique capabilities and requirements.

ICON

DRY LAB

Global community

Join one of the largest global networks of healthcare institutions to securely and anonymously share knowledge with your peers and confidently assess even challenging variants.

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BUNDLE

Unrestricted scalability

Benefit from a modular, web-based platform architecture enhanced by NVIDIA GPUs, enabling seamless adaptation to new technologies and increasingly larger datasets.

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DRY LAB